A Randomized, Parallel Group, Open Label, Multicenter Study to Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing with Clobetasol Propionate Cream (Impoyz™), 0.025% versus Clobetasol Propionate (Temovate®)
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چکیده
منابع مشابه
Cushing's syndrome and pituitary-adrenal suppression due to clobetasol propionate.
Widespread application of clobetasol propionate resulted in suppression of the hypothalamic pituitary axis in four patients. Three patients showed Cushigoid features and developed symptoms of adrenocortical insufficiency on withdrawal of clobetasol.
متن کاملObservations on the systemic effect of topical clobetasol propionate (Dermovate).
Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was suppressed when between 45 and 90 g was applied weekly. Insulin stress test results in patients with diseased skin showed an abnormally sma...
متن کاملEffect on adrenal function of topically applied clobetasol propionate (Dermovate).
Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured at intervals during treatment. A satis...
متن کاملNail psoriasis: a combined treatment using calcipotriol cream and clobetasol propionate cream.
Table I. Patients’ own opinion regarding eYcacy after 12 Sir, months Calcipotriol, a vitamin D derivative, has proven to be eVective in the treatment of nail psoriasis (1–4). The Hands (n= 48) Feet (n= 53) purpose of this open study was to evaluate the eYcacy n (%) n (%) and safety of the combined treatment of nail psoriasis Poor 3 (6.2) 6 (11.3 ) with calcipotriol cream and clobetasol propiona...
متن کاملTreatment of Localized Vitiligo with 1% Pimecrolimus Cream versus 0.05% Clobetasol Propionate Cream—Single, Blinded, Comparative Therapeutic Trial
Background: Calcineurin inhibitors like tacrolimus and pimecrolimus are new modality of treatment of localized vitiligo. Objective: To compare the effectiveness and side effects of 1% pimecrolimus cream in comparison with 0.05% clobetasol propionate cream as a treatment of localized type of vitiligo. Patients and Methods: Fifty two patients with localized vitiligo were included in this single, ...
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ژورنال
عنوان ژورنال: SKIN The Journal of Cutaneous Medicine
سال: 2018
ISSN: 2574-1624
DOI: 10.25251/skin.2.6.16